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IMMUNOHISTOCHEMISTRY
Utilizing advanced diagnostic techniques to evaluate protein expression of cells within tissues, IHC assists in identifying the distribution and localization of biomarkers.
IHC Markers
- Akt, protein kinase
- Alpha fetoprotein
- Anaplastic lymphoma kinase-1
- Annexin A1, hairy cell, B-cell lymphoma
- Androgen receptor
- Anti-Caldesmon, smooth muscle
- BCL2 follicular lymphoma, apoptosis inhibiting protein
- BCL6 follicle center B-cell
- CA 125 epitheliod malignancies ovary, breast
- CA 19-9 pancreas, liver, ovary, lung tumors
- Calcitonin
- Calretinin, calcium binding protein
- Carcinoembryonic antigen (CEA)
- Cathepsin D, breast carcinoma
- CD1a cortical thymocyctes, Langerhans cells
- CD2 thymic, T-cells, NK cell
- CD3 pan T-cell antigen
- CD4 helper T-cells
- CD5 pan T-cells, B-cell subset, thymic carcinoma
- CD7 pan T-cells, NK cells and thymocytes
- CD8 suppressor T-cells
- CD10 common acute lymphoblastic leukemia antigen
- CD15 epithelial, myeloid, Reed-Sternberg cell
- CD20 pan B-cell
- CD23 activated B-cells
- CD30 Ki-1 activated T-cells, B-cells, Reed-Sternberg cell
- CD31 endothelial cells technical only
- CD34 endothelial, stem cells, stromal cells
- CD43 T-cell, myeloid, B-cell subset, histiocyte
- CD45 leuocyte common antigen
- CD56 NK cell
- CD57 neural, neuroendocrine, NK cells
- CD68 macrophages
- CD79a B-cells, plasma cells
- CD138 plasma cells, subset epithelial cells
- CDX2 colorectal carcinoma
- Chromogranin A
- c-kit, myeloid and mast cell (CD117)
- Cyclin D1/PRAD1 mantle cell lymphoma
- Collagen IV, basement membrane protein
- Cytokeratin 5/6, squamous, mesothelial
- Cytokeratin 5 / p63 tumor suppressor gene cocktail
- Cytokeratin 5, p63, CK8/18 breast cocktail
- Cytokeratin 7, 54kD
- Cytokeratin 8; 35BH11
- Cytokeratin 8 (CAM5.2)
- Cytokeratin 8/18, adenocarcinoma
- Cytokeratin 19
- Cytokeratin 20
- Cytokeratin cocktail, PAN (AE1/AE3)
- Cytokeratin high molecular weight; 34BE12
- Cytomegalovirus
- D2-40, Podoplanin
- Desmin filament protein
- DOG1, derived from GIST 1
- E-cadherin epithelial cell, ductal-type breast carcinoma
- EGFR, epidernal growth factor receptor (HER1)
- Epithelial membrane antigen
- Epithelial related antigen (MOC-31)
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IHC utilizes enzyme-based reactions in conjunction with mono- or polyclonal antibodies to evaluate protein expression levels and locate sub cellular antigens in tissues
- ERCC1 excision repair cross complementing polypeptide
- Estrogen receptor
- Factor XIIIa fibrohistiocytic, dendritic interstitial cells
- Fascin, Hodgkin's lymphoma, Reed Sternberg cells
- Galectin-3, thyroid neoplasm, anaplastic LCL
- Gastrin, G-cell antral/pyloric mucosa
- Glycophorin-A
- Granzyme B, cytotoxic T-cell subset, NK cell
- Gross cystic disease fluid protein 15
- Hairy cell leukemia (DBA44)
- Helicobacter pylori
- Hepatocyte antigen (HEP Par-1)
- HER2/neu IVD
- Herpes Simplex virus type I and II
- HMB 45, melanoma associated marker
- Human glial fibrillary acidic protein
- Melanoma associated marker/Mart 1
- Inhibin, adrenal cortical, sex chord stromal
- Ki67 (MIB-1) cell proliferation marker
- Melanoma cocktail (HMB-45, Melan A)
- Microsatellite instability profile MLH1, MSH2, MSH6, PMS2
- Microsatellite instability MLH1
- Microsatellite instability MSH2
- Microsatellite instability MSH6
- MUM1, multiple myeloma oncogene 1
- Muscle specific actin
- Myeloperoxidase
- Myogenin muscle marker, habdomyosarcoma
- Myoglobin cardiac, skeletal
- Neurofilament
- Neuron-specific enolase (NSE)
- p16 tumor suppressor protein
- p21 WAF1 inhibitory gene
- p27Kip, kinase inhibitory protein 1
- p53 tumor suppressor gene protein
- p63 nuclear, tumor suppressor gene protein
- p63 plasma cell, tumor suppressor gene protein
- P504S gene product (AMACR) prostatic adenocarcinoma
- PAX-5, B-cell transcription factor
- pERK1/2, extracellular signal related kinase
- PIN-2 cocktail (P504S, CK HMW,) prostatic intraepithelial neoplasia
- PIN-4 cocktail (P504S,HMW CK, P63)
- Placental alkaline phosphatase, germ cell tumors, adenocarcinoma
- Platelet derived growth factor receptor (PDGFR) alpha
- Post Meiotic Segratation increased 2
- pRb, phosphorylated retinoblastoma suppressor protein
- ProEx™ C biomarker
- Progesterone receptor
- Prostatic acid phosphatase
- Prostate specific antigen (PSA)
- Renal cell carcinoma
- S-100 protein
- Smooth muscle actin
- Smooth muscle myosin
- Somatostatin, D-cells pancreatic islet cells
- Synaptophysin
- Survivin
- TAG 72, adenocarcinoma
- Terminal deoxynucleotidyl transferase, cortical thymocytes
- Thyroglobulin
- Thyroid Transcription Factor-1
- Tyrosinase
- Varicella zoster virus
- Vimentin
- Von Willebrand Factor VIII
- WT1, Wilms tumor
- ZAP 70, CLL/SLL prognosis
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